Rough-in dimensions decide the layout
Every bathroom drawing eventually meets a set of fixed numbers. A standard toilet rough-in is 12 inches from the finished wall to the centre of the flange, though 10 and 14 inch rough-ins turn up regularly in older Toronto houses and the toilet has to match. There is a minimum clearance either side of the toilet centreline and a required clear space in front. A tub waste has to sit where the joists allow an access point.
None of that is negotiable, and it is why a beautiful plan can fail on paper. A 36 inch vanity, a toilet and a linen tower along one 90 inch wall looks fine in a rendering and then loses to the clearance requirement by two inches.
We check the layout against the rough-in numbers before anything is ordered. If a plan does not work we say so early, and there are usually a couple of ways to rearrange it.